According to a recent study including almost 52,000 pregnant women in Canada, women who took nonsteroidal anti-inflammatory drugs (NSAIDs) had miscarriage rates that were more than twice as high as those of women who did not. According to a study that was published in the Canadian Medical Association Journal, women who took prescription NSAIDS for just four days in the early stages of pregnancy were more likely to miscarry.
These drugs, which are also available over-the-counter under the names Advil, Aleeve, or Ibuprofen, are frequently prescribed for pain, cramps, headaches, and fever. This study suggests that they might not be as safe as we previously believed in the early stages of pregnancy. Compared to 2.6% of women who did not fill a prescription, 7.5% of women who filled one for an NSAID during the first trimester of their pregnancy experienced a miscarriage. Ibuprofen, Naprosyn, Celebrex, and Diclofenac were among the prescriptions filled. Other miscarriage risk factors such as diabetes, depression, lupus, rheumatoid arthritis, and untreated thyroid disease were taken into account by the researchers.
The fact that the study primarily examined prescription NSAIDs raises concerns because it may not have included women who were taking NSAIDs over-the-counter. Prescription filing does not imply drug consumption on the part of the woman. Additionally, they observed that whilst only 3% of women who experienced miscarriages were prescribed anti-nausea medications, 15% of women who did not experience miscarriages were. It seems that experiencing morning sickness guards against miscarriage. Or the morning sickness medication has a preventive effect.
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What then should a woman do? First off, there is no need to concern if you used an NSAID while pregnant. There may have been other factors besides NSAIDs at play, and this trial was not flawlessly executed. Anxiety and depression were more common in the group that had miscarried. Furthermore, there was a much higher chance of having a healthy child than miscarriage.
It is recommended that women who are not pregnant take Tylenol, which contains acetaminophen, rather than an NSAID, for pain management.